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Mauricio Alvarez, Ph.D.

Mauricio Alvarez, Ph.D.

Patent Agent, New York

   Contact information

  • (646) 878-0852

Admitted

  • U.S. Patent & Trademark Office

Education

Albert Einstein College of Medicine, Ph.D. Microbiology & Immunology, 2008

Albert Einstein College of Medicine, M.Sc. Microbiology & Immunology, 2005

Lehman College, City University of New York, B.A. Biology, 2003

About Mauricio Alvarez, Ph.D.

Mauricio Alvarez is a Patent Agent in the Life Science Group of PCZL’s New York office, where he is currently handling patent drafting and prosecution matters.

Mauricio did his graduate work at the Albert Einstein College of Medicine, where he worked on host-pathogen interactions between the saprophytic fungi Cryptococcus neoformans and both murine and human macrophages. His work led to the discovery of a novel way that Cryptococcus can spread to and escape from macrophages, which could potentially play a significant role in Cryptococcal pathogenesis in immuno-competent and immuno-compromised individuals.

Throughout his graduate career, Mauricio concentrated on the fields of immunology, microbiology, and cell biology, where he made use of techniques ranging from Immuno-assays and cell sorting to electron and confocal microscopy. His work has been published in numerous well-known, peer-reviewed scientific journals.

Languages

English & Spanish

Publications

Chrisman CJ, Alvarez M, Casadevall A. Phagocytosis and non-lytic exocytosis of Cryptotoccus neoformans by and from Ancanthamoeba castellanii. Appl Environ Microbiol. 2010 Jul 30.

Alvarez M, Burn T, Luo Y, Pirofski LA, Casadevall A. The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes. BMC Microbiol. 2009 Mar 5;9:51.

Luo Y, Alvarez M, Xia L, Casadevall A. The outcome of phagocytic cell division with infectious cargo depends on single phagosome formation. PLoS ONE. 2008 Sep 16;3(9):e3219.

Alvarez M, Saylor C, Casadevall A. Antibody action after phagocytosis promotes Cryptococcus neoformans and Cryptococcus gattii macrophage exocytosis with biofilm-like microcolony formation. Cell Microbiol. 2008 Aug;10(8):1622-33. Epub 2008 Apr 1.

Rodrigues ML, Alvarez M, Fonseca FL, Casadevall A. Binding of the wheat germ lectin to Cryptococcus neoformans suggests an association of chitinlike structures with yeast budding and capsular glucuronoxylomannan. Eukaryot Cell. 2008 Apr;7(4):602-9. Epub 2007 Nov 26.

Alvarez, M and Casadevall, A. Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans and infection of murine macrophages. BMC Immunology.  2007 Aug 16;8:6.

Rodrigues ML, Nimrichter L, Oliceira DL, Frases S, Miranda K, Zaragoza O, Alvarez M, Nakouzi A, Feldmesser M,  Casadevall, A. Vesicular polysaccharide export in Cryptococcus neoformans is an eukaryotic solution to the problem of fungal trans-cell wall transport. Eukaryotic Cell. 2007 Jan;6(1):48-59. Epub 2006 Nov 17.

Alvarez, M and Casadevall, A. Phagosome extrusion and host-cell survival after cryptococcus neoformans phagocytosis by macrophages. Curr Biol. 2006 Nov 7;16(21):2161-5.

Wang F, Nakouzi A, Alvarez M, Zaragoza O, Angeletti RH, Casadevall A. Structural and functional characterization of glycosylation in an immunoglobulin G1 to Cryptococcus neoformans glucuronoxylomannan. Mol Immunol. 2006 Mar;43(7):987-98. Epub 2005 Jul 19.

Shao X, Mednick A, Alvarez M, van Rooijen N, Casadevall A, Goldman DL. An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia. J Immunol. 2005 Sep 1;175(5):3244-51.

Zaragoza O, Alvarez M, Telzak A, Rivera J, and Casadevall A. The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans infection is associated with pleiotropic differences in immune response. Infect Immun. 2007 Jun;75(6):2729-39. Epub 2007 Mar 19.

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